The crash happened on Rt 30 by Exit: PA 23 East - New Holland Ave/Pike and Exit: US 222 North - Ephrata/Reading around 10 p.m., according to PennDOT.
Emergency crews arrived at the scene to find multiple vehicles strewn across the roadway with patients trapped inside, as explained in a release by the Manheim Township Professional Firefighters.
It is unclear how many people were injured as of the time of publishing.
The roadway reopened two hours later. Check back here for possible updates.
Click here to follow Daily Voice Exeter Township and receive free news updates.